Alpha Lipoic Acid for Wrinkles with DMAE for saggy skin - 5 Stars!! 
(This had 4 stars before I figured out that if I used it at night too it REALLY had an effect!) 
Dr. Perricone Alpha Lipoic Acid Face Firming Activator You put this on right after you wash in the morning and at night. The Alpha Lipoic Acid protects skin, fighting off damaging free radicals, shrinking pores, evening skin tone and more. The DMAE firms sagging skin - some report it has a cumulative effect. Then you put on your hydroxy acids, like glycolic acid, followed by peptides if you like. $95 and worth it!
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I blew the wad to get this Dr. Perricone product after trying health food store imitations that were cheaper but that simply didn't work. This is a tiny pump, you use very little right after you wash, you wait a few minutes and then you put anything else on top of it. At first I used it just in the morning as advised by the Perricone pamphlet and, yes, I saw a little improvement. Then I decided, hey... I want this anti-inflammatory protection at night AND I want the DMAE tightening at night, too. So I put it on an hour AFTER I used my Renova one night and now I understand what the hub-bub is all about!
Dr. Perricone says that alpha lipoic acid with DMAE will improve the appearance of skin tone and texture, minimize large pores, fine lines, skin discolorations (age spots, redness), and resilience. Resilience is important for preventing new wrinkles or deepening old ones.
Here's how the ingredients work:
Alpha Lipoic Acid
Alpha lipoic acid is a very powerful antioxidant. Unlike Vitamin C (except Vitamin C ester) it is fat-soluble so it can penetrate the fatty part of a cell and unlike Vitamin E it is water-soluble. It not only protects ALL of a cell from free radical damage, even protecting DNA, but it strengthens the action of vitamins C and E and its action lasts longer. Facial scars and wrinkles improve and are repaired when alpha lipoic acid is applied topically but it does more than that. It can reverse under eye puffiness and eyelid bags -a result of inflammation, zap redness - a result of irritation, reduce the size of pores, and reduce fine lines and wrinkles. In one of Dr. Perricone's own studies with his patients, after 6 months of 2-times-a-day use, patients with acne scars enjoyed a 70-80% improvement. That's incredible. Pores, redness, inflammation and irritation - these are skin problems products like Renova and hydroxy acids can't solve. So the addition of alpha lipoic acid to a skin regimen to reverse skin aging is a must!
Dr. Perricone is one of the pioneers of the research on Alpha Lipoic Acid and its effects in cell protection extend beyond the skin to every cell in the body! Taking a supplement - or two - every day provides 10 times the protection of Vitamin C.
DMAE
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